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George O'Malley was born to Louise and Harold O'Malley, and was raised in or around Seattle, Washington. The O'Malleys were a close-knit if not wealthy family (Harold was a truck driver and Louise is a teacher), and Harold spent significant quality time with George and his brothers, Ronny and Jerry, during their childhoods. While Ronny and Jerry shared their father's interest in turkey hunting and classic cars, George was less enthusiastic about his family's hobbies, and as an adult would show some embarrassment over them.
While his brothers found careers in dry cleaning and postal service, George attended medical school at Oregon Health and Science University. After graduation and in spite of borderline test scores and qualifications, George secured a position in the surgical internship program at Seattle Grace Hospital.
Often the most emotional of the male doctors, he sometimes gets into arguments with others despite his more positive personality. His sensitive and sometimes bumbling personality have earned him a plethora of nicknames from the other interns – primarily Cristina Yang – including "Bambi" and "Fetus."
He has a markedly different personality from those of his brothers, one of whom accidentally shot his father in the buttocks on a Thanksgiving hunting trip. Despite his sometimes strained relationship with his family, George stepped up during his father's illness and showed his dedication to his brothers and mother.
Despite his disastrous "tragic sex" with Meredith and other numerous conflicts with all, George maintains that his three closest friends are Cristina, Meredith, and Izzie. He states that "they're my family", especially his best friend Izzie.
During the beginning of his internship, he was picked by Dr. Preston Xavier Burke to perform the first surgery of all the interns. During the surgery, he choked and earned the nickname "007" (after James Bond's License to Kill). In the next season , George and Alex Karev get stuck in an elevator with a patient who has been shot. The patient begins to bleed out and when Alex freezes up, Burke has to talk George through surgery and George "flies solo" for the first time.
George starts to date a nurse named Olivia in Season 1, from whom he eventually contracts syphilis, but later learned that she had gotten it from Alex who Olivia was seeing before she started to date George. George later dates Dr. Callie Torres, an orthopedic surgeon at Seattle Grace, but his poor treatment of her in Season 3 causes her to pull away. Later, he tries to fight for her.
During a camping trip, he not only learned from Alex that Callie had slept with Dr. Mark Sloan, but witnessed one of Burke's hand tremors. He confronted Cristina with his suspicions about Burke's problems after his father was diagnosed with esophageal cancer and a leaking aortic valve that would require surgery.
Concerned about Burke's current abilities as a surgeon, he contacted Dr. Erica Hahn to perform his father's valve replacement. His relationship with Callie was strained when he confronted her about her fling with Sloan, but as his father's condition deteriorated, George slowly allowed Callie to re-enter his life. George suffered a devastating loss when the difficult decision was made to take his father off life support after complications from cancer surgery left him in multi-system organ failure.
In an attempt to overcome the grief he experienced from his father's death, he secluded himself with his girlfriend and pursued an entirely sexual relationship. She begins to avoid him because she does not want to have that much sex, but he says that he would be happy to live with her and that he loves her. He asks her to marry him and they eloped to Las Vegas. Eight days have passed George and Callie enter, and George announces that he has married Callie in Las Vegas. This prompts Alex to laugh "Dude, she's Callie O'Malley". Izzie Stevens mocks Callie (and indirectly George) about the small size of her diamond ring.
Callie continually insists that George favors his friends (Izzie in particular) over her, and recently has had a serious fight where Callie told George that she feels that Izzie has feelings for him, and ultimately kicked him out of their hotel room. George then went to Izzie, confessing that he feels he may have made a mistake in marrying Callie, and that he wants to vent with alcohol. George ends up having sex with Izzie, and though he initially forgets this in the hangover haze, he later remembers and insists to Izzie that it remain their secret, and goes home with Callie, crushed by guilt. George is torn over what to do about both Izzie and Callie, for he has confided in Dr. Burke that he is "in love with two women." George put in for a transfer to nearby hospital Mercy-West, thinking the only way to resolve his feelings for Izzie is to be away from her. His request is granted, barring his success on the intern exam. After realizing how conflicted George is and not wanting to lose her best friend, Izzie lies to George and says that sleeping with him meant nothing and that she doesn't have feelings for him.
In the finale of the show's third season, Izzie admitted to being in love with George, who in turn, reacted strangely. It was revealed that George failed his intern exams and has decided to leave the hospital. When Miranda Bailey asks George if she had failed him, he replies: "No... I failed you". In the first episode of season 4 of the show, George seemed to have changed his mind and went ahead with repeating his internship. He takes a lot of humiliation in the process of doing so being known as the "failure" of the hospital. He also has a change of heart about his feelings for Izzie and tells her he loves her at the end of the episode. Later, in another episode, he finally tells Callie that he had an affair with Izzie. Callie tried to forgive him and shift all the blame to Izzie, but George says she cannot forgive what he did; Callie ends up agreeing. Callie then bluntly tells the rest of the hospital about George and Izzie. He breaks up with Izzie soon after due to a lack of chemistry, but continues to be good friends with her.
Initially, none of the interns knew that George was a repeat intern. Lexie kept his secret, and stayed by his side as a friend when all of the other interns find out about it. He moves in with her and starts accepting and living with what he has, befriending the other interns and hosting a party at their ugly apartment. In the season 4 finale, it is revealed that George failed the intern exam by only 1 point and received 14 outstanding letters of recommendation, making him and Lexie doubt his repeated internship even more. During a brief outburst at the chief, George is allowed to re-take the intern exam. When he comes home to Lexie, they share a brief celebratory kiss.
George finally passes his intern exam, after a little difficulty from a hospital flooding. Also during this time, he seems to treat Lexie with even less respect, someone who has been harboring feelings for him since the season 4 finale. The final straw occurs when he receives his new interns and Lexie discovers he hadn't the decency to even ask to have her assigned to him. She breaks down in front of him, calling herself stupid and him, a jerk. George tries to patch things up between them afterward, but Lexie starts to avoid him. Despite this, she finally decides to apologize and give a peace offering at the end of the night. Their friendship suffers nonetheless, in which she shuts him out of her life and doesn't tell him what's going on; even when she participates in a secret intern society.
He's tried to refocus on his friendship with Izzie, afterward, when he begins to worry that something's truly wrong with her. He continues to assist her in games for the interns, and other activities, and starts to notice signs of deteriorating health. As such, George asked Izzie many times if there was something wrong with her but she remained persistent that she was alright. When Izzie eventually admitted her illness to Cristina, and was admitted to the hospital, he was angry and disappointed that she chose to go to Cristina with her sickness and not himself. He even shut himself off to smashing bones when she was undergoing a procedure; however, after some encouraging words from Callie, George chose to finally support his friend. Furthermore, he exchanged harsh words with Alex while coping with the possibility of losing his friend, as well as losing her love to Alex. During her wedding with Alex, however, George walked a weak Izzie to the altar.
During this time, George started showing a talent for trauma surgery, a talent that eventually gained the attention of Dr. Owen Hunt. Hunt would eventually become his mentor and teacher, offering him advice and help. After an Iraq veteran comes to Seattle Grace to receive a prosthetic leg, George enlists for the army as a trauma surgeon, which shocks Bailey. Along with Callie and the rest of George's fellow residents, Bailey stages an intervention to convince George to stay in Seattle. Their plans are cut short when a trauma case arrives, a John Doe who was hit and dragged by a bus for meters after pushing away a woman who was almost hit instead. When Callie and Bailey later team up to get George out of the surgery he scrubbed in for, the Chief informs them he sent George home, since he was leaving for the army the next day. At the same time, the trauma patient wakes up and writes "007" on Meredith's hand. ("007," a reference to James Bond and his licence to kill, was a nickname given to George by his fellow interns when he almost lost his first patient during a routine procedure in the first season.) She realizes in horror their John Doe is, in fact, George. She informs the rest and they rush him to surgery. He codes during this time and meets up with best friend Izzie in a heaven-like scene.
George died. Izzie decides for him, with Callie's help that they will harvest all of his vital organs for donation. He is laid to rest and everyone at Seattle Grace copes with his death in various ways.
Aliases: Bambi, 007, Curious George, Georgie, Irish, O'Malley, Foetus, Syph-Boy
Strengths: Kind-hearted; compassionate; loyal; excellent bedside manner; great at calming patients
Weaknesses: He can get a little too involved with patients, and, as marrying Callie on the spur of the moment demonstrates, he can be very impulsive.
Likes: Scrubbing in; strengthening friendships; looking good in front of the Chief
Dislikes: Repeating his intern year; operating on family; Thanksgiving hunting trips; picking a car; being emasculated.
Occupation: Surgical Resident at Seattle Grace Hospital
Family:
Louise O'Malley (mother)
Harold O'Malley (father, deceased)
Jerry O'Malley (brother)
Ronny O'Malley (brother)
Spouse(s):
Dr. Callie Torres (ex-wife)
Dr. Izzie Stevens (ex-girlfriend)
Dr. Meredith Grey (one-night stand)
Olivia Harper (ex-girlfriend)